Process for preparing conjugates of methyltrithio antitumor agen

Details Process for preparing conjugates of methyltrithio antitumor agen Process for preparing conjugates of methyltrithio antitumor agen

1995-05-26

1999-03-02

Achutamurthy, Ponnathapura

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

514 25, 514 26, 514 53, 514168, 5303911, 5303919, C07K 1600, A01N 4304, C12P 1944

Patent

active

058772960

ABSTRACT:
This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

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