Process for preparing compositions containing neotrehalose

Details Process for preparing compositions containing neotrehalose Process for preparing compositions containing neotrehalose

1994-09-30

1998-02-03

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435100, 426658, A61K 31715, C12P 1912, A23G 300

Patent

active

057144761

ABSTRACT:
Neotrehalose is prepared in a relatively high-yield by a process comprising allowing .beta.-galactosidase to act on a solution containing lactoneotrehalose to form neotrehalose and recoverying the resultant neotrehalose. The neotrehalose is a non-reducing oligosaccharide having a satisfiable stability and a rich- and high-quality-sweetness and is assimilated and utilized as energy source in vivo when orally administered. Neotrehalose in the form of crystal has a satisfiable handleability because it is readily soluble in water and substantially free of hygroscopicity. These render neotrehalose very useful in the fields of food-, cosmetic- and pharmaceutical-industries.

REFERENCES:
patent: 5403727 (1995-04-01), Miwa et al.
Chemical Abstracts 110(9): 74133g (1989) (Kobayashi et al).
Haworth et al., J. Chem. Society, 2847-2850 (1931).
Bradling et al., Carb. Res., 126, 125-156, (1984).
Paulson et al., J. Biol. Chem., 253(16), 5617-5624 (1978).
Sharp et al., J. Chem. Society, 258-288 (1951).
Onishi et al., Chemical Abstracts, 76(21),CA127294y (1970).
Kobayashi et al; Foods containing trehalose with good anticaries and Bifidobacterium growth-promoting activities; Chemical Abstracts; vol. 110; No. 74134; p. 525; Oct. 6, 1988.
Kobayashi et al; Enzymatic manufacture of neotrehalose and centose; Chemical Abstracts; vol. 110; No. 152832; p. 593; Sep. 8, 1988.
Ajisaka et al; Regioselective syntheses of trehalose-containing trisaccharides using various glycohydrolases; Carbohydrate Research; vol. 199; pp. 227-234; 1990.

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