Process for preparing clotrimazole

Details Process for preparing clotrimazole Process for preparing clotrimazole

1990-03-28

1992-02-25

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23354

Patent

active

050915401

ABSTRACT:
A process for preparing clotrimazole by reacting 2-chlorotriphenylmethylchloride with imidazole in a hydrocarbon solution in the presence of a neutralizing agent, followed by nitration of the product obtained. The nitrate is reconverted into the free base with caustic alkali.

REFERENCES:
patent: 2215862 (1940-09-01), Waldmann et al.
patent: 3929820 (1975-12-01), Buchel

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