Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Reexamination Certificate
2005-06-14
2005-06-14
Kerr, Kathleen (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
Reexamination Certificate
active
06905849
ABSTRACT:
The present invention relates to a new process for the synthesis of clavam compounds, in particular clavulanic acid. In one aspect, the invention relates toStreptomyces clavuligerusβ-lactam synthetase polypeptide sandStreptomyces clavuligerusβ-lactam synthetase polynucleotides, recombinant materials thereof and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides.
REFERENCES:
patent: 6232106 (2001-05-01), Jensen et al.
patent: 6514735 (2003-02-01), Jensen et al.
patent: 6589775 (2003-07-01), Jensen et al.
patent: 2108113 (1995-04-01), None
patent: WO 94/12654 (1994-06-01), None
Jensen et al. Biosynthesis and molecular genetics of clavulanic acid. Antonie Van Leeuwenhoek (1999) (1-2): 125-133.
Li et al. Expansion of the Clavulanic Acid Gene Cluster: Identification and In Vivo Functional Analysis of Three New Genes Required for Biosynthesis of Clavulanic Acid byStreptomyce clavuligerus. Journal of Bacteriology (2000) 182(14): 4087-4095.
McNaughton, et al., “β-Lactam Synthetase: Implications for β-Lactamase Evolution”.Chem. Commun., 21: 2325-2326 (1998).
Bachmann, et al., “β-Lactam Synthetase: A New Biosynthetic Enzyme”.Proc. Natl. Acad. Sci. USA, 95: 9082-9086 (1998).
Barton Barry
McNaughton Heather Jane
Schofield Christopher Joseph
Thirkettle Jan Edward
Kerr Kathleen
Lockenour Andrea V.
SmithKline Beecham plc
Sutton Jeffrey A.
LandOfFree
Process for preparing clavam derivatives by using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing clavam derivatives by using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing clavam derivatives by using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3474103