Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-08
2011-03-08
Anderson, Rebecca L (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S242000, C548S360500, C549S419000
Reexamination Certificate
active
07902376
ABSTRACT:
A novel process is provided for the preparation of chiral trans-2,3-disubstituted 5-oxotetrahydropyrans of structural formula (I):wherein Ar is optionally substituted phenyl and P is a primary amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
REFERENCES:
patent: 2007/0232676 (2007-10-01), Biftu et al.
patent: WO 2007/126745 (2007-11-01), None
patent: WO 2007/126745 (2007-11-01), None
patent: WO 2007/126745 (2007-11-01), None
Kim Mary M.
Kohmura Yoshinori
Rosen Jonathan D.
Sladicka Tricia
Xu Feng
Anderson Rebecca L
Banyu Pharmaceutical Co. Ltd.
Fair Janet E.
Merck Sharp & Dohme Corp.
Otton Alicia L
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