Process for preparing chiral cyclopropane carboxylic acids and a

Details Process for preparing chiral cyclopropane carboxylic acids and a Process for preparing chiral cyclopropane carboxylic acids and a

1999-06-10

2000-12-12

Huang, Evelyn Mei

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546332, 548125, 5483415, 5483761, 549467, 549471, 549 78, 549385, 549398, 562401, 562506, C07D30787, C07D30779, C07D30780, C07C 6104, C07C 49293

Patent

active

061601349

ABSTRACT:
A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of the structure ##STR1## which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors.

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March J. Advanced Organic Chemistry. Second edition. P. 73, 1977.
Falmagne, J-B. et al, "Cyclobutanone and Cyclobutenone Derivatives by Reaction of Tertiary Amides with Alkens or Alkynes" Agnew. Chem. Int. Ed. Engl. 20 (1981) No. 10.
Houge, C. et al, "Models for Asymmetric [2+2]Cycloadditions" J. Am. Chem. Soc., 1982, 104, 2921-2923.
Schmit, C. et al, "A General Synthesis of Cyclobutanones from Olefins and Tertiary Amies: 3-Hexylcyclobutanone" Org. Synth. 1990, 60, 199.

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