Process for preparing chiral aromatic α-hydroxy...

Details Process for preparing chiral aromatic α-hydroxy... Process for preparing chiral aromatic α-hydroxy...

2007-01-23

2007-01-23

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S315000, C568S319000

Reexamination Certificate

active

10502426

ABSTRACT:
A biotransformation process for preparing chiral aromatic-hydroxy ketones in high yields is described, using 2-hydroxy-3-oxoacid synthase, such as AHAS or TSAS. Optionally substituted arylaldehydes and -oxoacids react in this process to provide pure enantiomers, useful as synthons in the production of various drugs, an example being (R)-phenylacetyl carbinol.

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