Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-06-11
1987-07-21
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546314, C07D21182
Patent
active
046819444
ABSTRACT:
There is described a novel process for preparing 4-pyridinylmethyl ketones of formula (I) ##STR1## wherein R is alkyl, aryl or aralkyl. The process involves hydrolysis of a compound ##STR2## generated by reaction of an acylating agent with 4-methylpyridine. The acylating agent may be selected from compounds of formula R-CO-X and R-CO-O-CO-R where R is as defined above and X represents halogen. Compounds of formula I have utility in the preparation of a variety of products, including pharmaceutically active 1,2-dihydro-6-R-2-oxo-5 pyridinyl compounds.
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Anders et al., Chemische Berichte, vol. 116(9), pp. 3192-3201, Sep. 1983.
March, Advanced Organic Chemistry, Reactions, Mechanisms and Structure, Second Edition, p. 441, McGraw-Hill Pub. QD 251 M2 1977 C.5.
Gutsche and Voges, "Acylation and Other Reactions of 2- and 4-Pyridinylacetonitriles", Sep. 1967, pp. 2685-2689.
Ippolito Robert M.
Vigmond Stephen
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