Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1977-07-18
1979-04-10
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424246, 260239A, C07D50102
Patent
active
041489950
ABSTRACT:
Cephem lactones of formula (1) ##STR1## wherein R.sup.1 is hydrogen or an organic substituent of the type appearing as the 6-substituent of penicillins or as the 7-substituent of cephalosporins are produced from corresponding 4,5-halohydrin precursors thereof by dehalogenation. Novel stereoisomers of formula (1) compounds as well as novel intermediates for cephem lactone syntheses are disclosed.
The cephem lactones produced according to the invention are of utility as intermediates for cephem-type antibiotics and have antibiotic properties of their own.
REFERENCES:
patent: 3708477 (1973-01-01), Martel et al.
patent: 3905965 (1975-09-01), Martel et al.
patent: 4016158 (1977-04-01), Martel et al.
Petrzilka Theodor
Prasad Kapa K.
Schmid Gerard
Kleeman Werner W.
Petrzilka Theodor
Rizzo Nicholas S.
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