Process for preparing cephalosporin compounds from 7-ADCA

Details Process for preparing cephalosporin compounds from 7-ADCA Process for preparing cephalosporin compounds from 7-ADCA

1974-07-02

1976-05-18

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50106

Patent

active

039577732

ABSTRACT:
7.beta.-Amino-3-methylceph-3-em-4-carboxylic acid is converted to cephalexin in high yield and relatively uncontaminated with unreacted 7.beta.-amino-3-methylceph-3-em-4-carboxylic acid if it is silylated prior to acylation with phenyl glycyl chloride hydrochloride and if the acylation reaction is conducted in dimethylformamide at low temperature in the presence of certain weak tertiary nitrogen bases.

REFERENCES:
patent: 3694437 (1972-09-01), Jackson
patent: 3743644 (1973-07-01), Essery et al.
patent: 3769280 (1973-10-01), Parker
patent: 3809699 (1974-05-01), Ishimaru
patent: 3843639 (1974-10-01), Sapino et al.

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