Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-04-14
1996-05-14
Rizzo, Nicholas
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D50104
Patent
active
055169023
ABSTRACT:
Chromogenic and fluorogenic substrates for .beta.-lactamase, methods for synthesis thereof and methods for detecting .beta.-lactamase in a sample are provided. The substrates are substantially colorless or substantially nonfluorescent .beta.-lactam compounds which include an electronegative leaving group. The leaving group comprises a carbamate, carbonate, thiocarbamate or thiocarbonate linkage and a fluorescent moiety or a moiety capable of producing a visually detectable colored product. Upon cleavage of the lactam ring by .beta.-lactamase, the leaving group is liberated and fluorescence or a colored product is produced.
REFERENCES:
patent: 5043334 (1991-08-01), Bell et al.
Hoke Randal A.
Millner, deceased O. Elmo
Mize Patrick D.
Quante J. Michael
Woodard Daniel L.
Becton Dickinson and Company
Fugit Donna R.
Rizzo Nicholas
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