Process for preparing cephalexin monohydrate

Details Process for preparing cephalexin monohydrate Process for preparing cephalexin monohydrate

1990-05-10

1992-08-25

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540228, C07D50104

Patent

active

051420430

ABSTRACT:
Cephalexin monohydrate prepared by the silylation of 7-ADCA is obtained in high yield and of improved purity when the silylation step is carried out by refluxing in a solvent having a boiling point of over 100.degree. C.

REFERENCES:
patent: 3499909 (1970-03-01), Weissenburger et al.
patent: 3694437 (1972-09-01), Jackson
patent: 4223135 (1980-09-01), Walker et al.
patent: 4316017 (1982-02-01), Walker et al.
patent: 4504657 (1985-03-01), Bouzard et al.
Bortesi et al., Preparation, Identification, and Quantitive NMR Determination of Silyl Derivatives of 6-Aminopenicillanic Acid, 7-Amino-3-Methyl-3-Cephem 4-Carboxylic and 7-Amino-3-Acetoxymethyl-.sup.3 -Cephem-4-Carboxylic Acid, vol. 66, No. 12 (Dec. 1977) pp. 1767-1769.
Bruynes et al., Catalysts for Silylations with 1,1,1,3,3,3-Hexamethyldisilazane, American Chem. Soc. (1982).

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