Process for preparing cefuroxime axetil

Details Process for preparing cefuroxime axetil Process for preparing cefuroxime axetil

1988-10-18

1991-05-07

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50102

Patent

active

050138332

ABSTRACT:
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.
Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.
Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.

REFERENCES:
patent: 4002748 (1977-01-01), Bornstein et al.
patent: 4267230 (1981-05-01), Gregson et al.
patent: 4562181 (1987-12-01), Crisp et al.

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