Process for preparing ceftazidime pentahydrate

Details Process for preparing ceftazidime pentahydrate Process for preparing ceftazidime pentahydrate

1990-11-26

1991-06-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50138

Patent

active

050215647

ABSTRACT:
An improvement in the process of preparing ceftazidime pentahydrate from ceftazidime dihydrobromide which comprises commingling a secondary-amine-type ion-exchange resin such as Amberlite LA-2 in a water-immiscible organic solvent with an aqueous solution of the dihydrobromide, stirring the mixture while maintaining a pH at or below about 6.0 and isolating ceftazidime pentahydrate from the aqueous layer. This process provides significantly higher yields of the pentahydrate than previously could be obtained from the dihydrobromide.

REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4329453 (1982-05-01), Brodie et al.
patent: 4537959 (1985-08-01), Chou
patent: 4616080 (1986-10-01), Chou
Glaxo Group Ltd., Derwent Abstract No. 85-321449/38 of German Patent No. 3,508,572-A, issued Mar. 8, 1985.

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