Process for preparing carboxylated organic compounds

Details Process for preparing carboxylated organic compounds Process for preparing carboxylated organic compounds

1981-06-30

1984-03-06

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 58, 549 71, 549499, 260413, 2604654, 560 97, 560105, 560114, 560204, 560206, 560232, 562406, 562489, 562497, 562520, C07C 5110

Patent

active

044355750

ABSTRACT:
A process is herein described for preparing carboxylated organic compounds (acids, esters, alkaline salts) of formula ##STR1## wherein R is a hydrocarbyl group having up to 11 carbon atoms (an aliphatic, alicyclic, aryl- or heteroarylalkyl group), also substituted, in its turn, by groups inert under the reaction conditions (alkyl, aryl, etheric, thioetheric, halogen, nitrile, ester, amide, ketonic groups), and R' is a hydrogen atom or an alkyl C.sub.1 -C.sub.8 group, by reaction of carbon monoxide with the corresponding hydrocarbyl halides, having the halogen bound to a non-tertiary carbon atom, in the presence of catalysts which are salts of cobalt hydrocarbonyl, or precursors thereof, in a hydro-alcoholic or alcoholic solvent and in the presence of bases.
The process is characterized in that the catalytic system composed by the salt of cobalt hydrocarbonyl is supported on an anion exchange resin. The process permits to operate also continuously, in any case allowing an easy recovery, recycle and regeneration of the catalysts.
The products obtained, i.e. carboxylic acids, esters and alkaline salts thereof, are utilized as intermediates for organic syntheses particularly for fine chemistry (phytopharmaceuticals, pharmaceuticals, etc.).

REFERENCES:
patent: 3116306 (1963-12-01), Heck
patent: 3708529 (1973-01-01), Cassar et al.
patent: 4128572 (1978-12-01), Cassar et al.
patent: 4328125 (1982-05-01), Drago et al.
Calmon et al., Ion Exchangers in Organic and Biochemistry, Interscience (1957), pp. 662-665.
Grubbs, Chemtech., 1977, pp. 512-518.
Nagy-Magos et al., J. of Organometallic Chem., 14 (1968), pp. 205-210.
Yermakov, Catal. Rev.-Sci. Eng., 13 (1), (1976), pp. 77-120.

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