Process for preparing carboxyalkyl dipeptides

Details Process for preparing carboxyalkyl dipeptides Process for preparing carboxyalkyl dipeptides

1986-12-29

1989-02-28

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C07F 710

Patent

active

048087416

ABSTRACT:
Pharmaceutically active carboxyalkyl dipeptides such as enalapril, lisinopril and the like, are prepared from a starting amino acid such as L-alanine, by protecting the acid function of the amino acid with an alkyl silyl protecting group, while it is reacted with an .alpha.-halo ester, at its amino function. Subsequently, the silyl protectant is removed, and the acid group is reacted with the amino function of an appropriate amino acid such as L-proline, to form the dipeptide product.

REFERENCES:
patent: 2789122 (1957-04-01), Cason et al.
patent: 3517041 (1970-06-01), Schaar et al.
patent: 3864373 (1975-02-01), Seiler et al.

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