Process for preparing carbamyl derivatives of .alpha.-hydroxy ac

Details Process for preparing carbamyl derivatives of .alpha.-hydroxy ac Process for preparing carbamyl derivatives of .alpha.-hydroxy ac

1980-09-17

1982-06-01

Warden, Robert J.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C07B 1902

Patent

active

043329055

ABSTRACT:
This invention relates to a process for preparing carbamyl derivatives of .alpha.-hydroxy acids by the hydrolysis of 5-substituted 2,4-oxazolidinediones.
The carbamyl derivatives can be further hydrolyzed to .alpha.-hydroxy acids.
The invention also relates to a process for the enzymatic hydrolysis of racemic 5-substituted 2,4-oxazolidinediones to give only one of the two possible optical isomers, i.e. the D-carbamyl-.alpha.-hydroxy acid. The free D-.alpha.-hydroxy acid can be obtained from the optically active carbamyl derivative by simple hydrolysis. Of particular interest is the case in which the D-.alpha.-hydroxy acid is D(-)mandelic acid. The enzymatic activity required for preparing the carbamyl derivative of D(-)mandelic acid has been found both in homogenized veal liver and in a series of microorganisms, including Agrobacterium radiobacter, Bacillus brevis, Bacillus stearothermophilus, Pseudomonas sp., Pseudomonas desmolytica, Pseudomonas fluorescens, Pseudomonas putida.

REFERENCES:
patent: 4065353 (1977-12-01), Cecere et al.
patent: 4237227 (1980-12-01), Yamada et al.
patent: 4242452 (1980-12-01), Yamada et al.
Jesse P. Greenstein and Milton Winitz, Chemistry of the Amino Acids, John Wiley & Sons, Inc., vol. 2, pp. 860-863, 1961.
Chemical Abstracts, vol. 91, 170502m, 1979.

Affiliated with

Also associated with

Rating

Process for preparing carbamyl derivatives of .alpha.-hydroxy ac does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing carbamyl derivatives of .alpha.-hydroxy ac, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing carbamyl derivatives of .alpha.-hydroxy ac will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1850300