Process for preparing bovine pericard materials and use thereof

Details Process for preparing bovine pericard materials and use thereof Process for preparing bovine pericard materials and use thereof

1994-04-06

1995-05-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Carbonate

424722, 424680, 514801, 530356, 623 16, A61K 3314, A61K 3712, A61F 228

Patent

active

054137985

ABSTRACT:
A process for treating bovine pericard tissue to increase resistance to biological degradation by wet-chemical processing, The wet-chemical processing consists essentially of: (i) separating any adherent fat and basal membrane from the tissue; (ii) contacting the tissue with an aqueous, alkaline solution of sodium hydroxide, potassium hydroxide, lithium hydroxide or sodium carbonate to swell the tissue; (iii) contacting the swollen tissue with an aqueous sodium chloride solution to control the swelling; (iv) contacting the tissue with a solution of a metal-ion complexing agent with a pH in excess of 11; and (v) contacting the tissue with an aqueous buffer solution having a pH of 4.5 to 6.0. Each of steps (ii)-(v) is followed by a water rinse. The pericard tissue is then dried and sterilized.

REFERENCES:
patent: 4006083 (1977-02-01), Westervelt et al.
patent: 4502159 (1985-03-01), Woodroof et al.
patent: 4776853 (1988-10-01), Klement et al.

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