Process for preparing BIS-indolyl macrocycles

Details Process for preparing BIS-indolyl macrocycles Process for preparing BIS-indolyl macrocycles

1997-03-20

1998-04-14

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540471, 540460, C07D49822, C07D22314

Patent

active

057393222

ABSTRACT:
This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## wherein R1, R2, X, W, and Y are as defined in the specification. The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.

REFERENCES:
patent: 4785085 (1988-11-01), Kaneko et al.
patent: 4808613 (1989-02-01), Kaneko et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5043335 (1991-08-01), Kleinschroth et al.
patent: 5057614 (1991-10-01), Davis et al.
patent: 5292747 (1994-03-01), Davis et al.
patent: 5380746 (1995-01-01), Barth et al.
patent: 5438050 (1995-08-01), Kleinschroth et al.
patent: 5481003 (1996-01-01), Gillig et al.
Derwent Abstract 90-132947/18; 21.10.88-DE-835842 (1990).
Derwent Abstract 92-274042/33;90.11.20 90JP-314628 (1992).
Meier, et al., Tetrahedron Letters, 34:33, 5277-5280 (1993).
Wilkinson, et al., Bichem. J., 294, 335-337 (1993).
Bit, et al., J. Med. Chem., 36, 21-29 (1993).
Martiny-Baron, et al., The Journal of Biological Chemistry, 268:13, 9194-9197 (1993).
Krakowiak, et al, Synlett, 611-620, (Sep. 1993).
Mulqueen, et al., Agents Actions, 37, 85-89 (1992).
Davis, et al., J. Med. Chem., 35, 177-184 (1992).
Davis, et al., J. Med. Chem., 35, 994-1001 (1992).
Toullec, et al., The Journal of Biological Chemistry, 266:24, 15771-15781 (1991).
Nixon, et al., Drugs Exptl. Clin. Res., 17:8, 389-393 (1991).
Davis, et al., Tetrahedron Letters, 31:36, 5201-5204 (1990).
Brenner, et al., Tetrahedron Letters, 44:10, 2887-2892 (1988).
Joyce, et al., The Journal of Organic Chemistry, 52:7, 1177-1186 (1987).
Buchdunger, et al., Proc. Natl. Acad. Sci. USA, 91, 2334-2338 (Mar. 1994).
Kobayashi, et al., The American Physiological Society, H1214-H1220 (1994).
Felsenstein, et al., Neuroscience Letters, 174 173-176 (1994).
Demaerschalck, et al., Biochimica et Biophysica Acta, 1181 214-218 (1993).
Shimohama, et al., Neurology, 43 1407-1413 (1993).
Fieser and Fieser, Reagents for Organic Synthesis, XII, John Wiley & Sons, p. 108 (1986).
Stork, et al. J. Org Chem., 61 paper 3093-3105 (1996).
KiKugawa, et al., Synthesis, 461-2, (1981).
Cremlyn, et al.: J.C.S. Perkin 500-3 (1973).
Santaniello, et al., Synthesis; 617-618 (1979).

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