Process for preparing bis-indolyl macrocycles

Details Process for preparing bis-indolyl macrocycles Process for preparing bis-indolyl macrocycles

1997-11-14

1998-10-13

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540460, 540471, 540472, C07D49822, C07D48722

Patent

active

058213651

ABSTRACT:
This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## wherein R.sub.1, R.sub.2, X, W, and Y are as defined in the specification. The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.

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