Process for preparing biotin

Details Process for preparing biotin Process for preparing biotin

1975-06-30

1977-08-23

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260307G, 2603322H, 260481R, C07D49504

Patent

active

040440206

ABSTRACT:
Biotin is prepared by (a) ozonizing methylcyclohexene; (b) reacting nitromethane with the methyl-6-oxohexanoate from a to form 7-nitro-6 hydroxyheptanoic acid methyl ester; (c) acylating to form the corresponding 6 acyloxy compound; (d) forming a double bond at the 6 position; (e) reacting the product of d with nitroethanethiol to form dl-7-thia-6-nitromethyl-9-nitro-nonanoic acid methyl ester; (f) forming a furoxan by cyclization; (g) reducing the furoxan and acylating to form dl-2(4-carbomethoxybutyl)-3,4-bis(acylamido)-2,5-dihydro thiophene; (h) selectively hydrogenating to form the 3,4-cis-bis(acylamido)-2,5-dihydro thiophene; and (i) hydrolyzing and cyclizing to form dl-biotin. The products formed at steps (e)-(h) are novel, as are the individual steps (e), (f), (g), and (h).

REFERENCES:
patent: 2417326 (1947-03-01), Schnider et al.
patent: 2437719 (1948-03-01), Wolf et al.

Affiliated with

Also associated with

Rating

Process for preparing biotin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing biotin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing biotin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2315273