Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer
Patent
1997-10-01
1999-08-31
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Aftertreated solid synthetic organic polymer
514 2, 514 56, 424422, 424423, 424425, 424426, 427 224, 427 225, 427 226, 523112, 523113, 524916, 5262381, 5262382, 52623823, 526259, 526263, 526271, 526272, 526304, A01N 100, A01N 102
Patent
active
059454571
ABSTRACT:
A hemocompatible composition comprising a polymer containing at least one pharmacologic material chemically bonded to a polymer backbone. Such compositions may be obtained by reacting a pharmacologic material with a compound containing a polymerizable group (e.g., an acyl halide) and thereafter either copolymerizing the acylated material with one or more copolymerizable monomers or first irradiating a backbone polymer and thereafter grafting the acylated pharmacologic material onto the irradiated polymer. The resulting products are hemocompatible and may be used in the manufacture of medical devices which come in contact with blood or other bodily fluids. The advantage of chemically bonded pharmacologic materials is that they are not leached out and retain their pharmaceutical effectiveness for a long period of time. The compositions may contain one or more additional pharmacologic materials which are physically admixed with polymers containing bonded pharmacologic materials.
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Plate Nicolai A.
Sinani Vladimir A.
Uzhinova Lubov D.
Valuev Lev I.
A.V. Topchiev Institute of Petrochemical Synthesis, Russian Acad
Krass Frederick
Shust Nestor W.
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