Chemistry: physical processes – Physical processes – Crystallization
Patent
1977-08-22
1978-10-24
Serwin, R.E.
Chemistry: physical processes
Physical processes
Crystallization
23230R, 252408, G01N 3316
Patent
active
041219058
ABSTRACT:
The present disclosure is directed to the preparation of stable aqueous-containing biological compositions capable of use as liquid reference serums in diagnostic chemical analysis using multichannel automated analyzers and having improved storage stability and capable of storage in the liquid state for extended periods of time measured in weeks when stored at 2.degree. to 8.degree. C.; processes for preparing the reference serums and the process of automated analysis utilizing the improved reference serums. The subject materials are prepared by freezing the aqueous-containing labile biologicals rapidly at temperatures ranging from about -20.degree. to about -30.degree. C., removing from about 98 to 99 weight percent of the water therefrom and storing same (as a dehydrated solid) at 2.degree. to 8.degree. C. until desired use. The dehydrated material is then reconstituted by dissolving it in a medium containing from about 20 to about 50 wt. % of an alkylene polyol containing from 2 to 5 carbon atoms with the remainder being water. The thus reconstituted biological compositions can be stored in the liquid state at 2.degree. to 8.degree. C. for periods of 4 to 5 weeks or at -20.degree. C. for months.
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Burke Joseph Patrick
Serwin R.E.
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