Process for preparing biodegradable submicroscopic particles con

Details Process for preparing biodegradable submicroscopic particles con Process for preparing biodegradable submicroscopic particles con

1982-02-17

1984-12-18

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424 11, 424 9, 424 19, 424 22, 424 33, 424 88, 424 91, 424 92, 424 93, 424 94, 42721331, 42721334, 42840224, 436172, G01N 3348, A61J 300, A61K 4900, B01J 1302

Patent

active

044890559

ABSTRACT:
Biodegradable particles, with a diameter smaller than 500 nanometers, formed by the micellar polymerization of an alkyl-cyano-acrylate where the term "alkyl" means a lower alkyl radical having 1 to 4 carbon atoms and containing a biologically active substance. Also provided are processes for making pharmaceutical compositions containing the biodegradable particles and using the particles in pharmaceutical and diagnostic applications.

REFERENCES:
patent: 2776232 (1957-01-01), Shearer, Jr. et al.
patent: 2912454 (1959-11-01), McKeever
patent: 3185625 (1965-05-01), Brown
patent: 3415758 (1968-12-01), Powell et al.
patent: 3544500 (1970-12-01), Osmond et al.
patent: 3660304 (1972-05-01), Matsukawa
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4269821 (1981-05-01), Kreuter et al.
patent: 4329332 (1982-05-01), Couvreur et al.
Coover, Jr., et al.: "Chemistry and Performance of Cyanoacrylate Adhesives", Soc. Plastics Eng. J., 15-413, (1959).
Donnelly et al.: "Ionic and Zwitterionic Polymerization of N-Alkyl-2-Cyanoacrylates", Polymer Letters Edition, vol. 15, pp. 399-405, (1977).
Couvreur et al.: "Nanokapseln: Ein Never Lysosomotropischer Trager", Acta Pharmaceutica Technologica, Supplement 7/1978.
Couvreur et al.: "Nanocapsules: A New Type of Lysosomotroac Carrier", Febs. Letters, 84 (2): 323-326, (1977).
Couvreur et al.: "Adsorption of Antineoplastic Drugs to Polyalkylcyanoacrylate Nanoparticles . . . ", J. of Pharmaceutical Sciences, vol. 68, No. 12, Dec. 1979.
Couvreur et al.: "Tissue Distribution of Antitumor Drugs Associated with Polyalkylcyanoacrylate Nanoparticles", J. of Pharmaceutical Sciences, vol. 69, No. 2, Feb. 1980, (199-202).
Kante et al.: "Tissue Distribution of [.sup.3 H] Actinomycin D Adsorbed on Polybutylcyanoacrylate Nanoparticles", Internat'l J. of Pharmaceutics, 7 (1980), 45-53.
Brasseur et al.: "Actinomycin D Adsorbed on Polymethylcyanoacrylate Nanoparticles: . . . ", Europ. J. Cancer, vol. 16, pp. 1441-1445, (1980).
Clayton: "Colloid Aspects of Food Chemistry and Technology", J. & A. Churchill, London, 1932, p. 116.
Winnacker et al.: "Chemie Organique", Paris, 1969, p. 583.
Birrenbach et al.: "Polymerized Micelles . . . ", J. of Pharmaceutical Sciences, vol. 65, No. 12, Dec. 1976, pp. 1763-1766.
Chem. Abstracts, vol. 83, No. 3, Aug. 1975, p. 305, 48195h and 48196j, (Tomoegawa).
Chem. Abstracts, vol. 88, No. 18, May 1978, p. 322, 126303m, (Couvreur et al.).
Chem. Abstracts, vol. 88, No. 24, Jun. 1978, p. 426, 177057s, (Marty et al.).
Chem. Abstracts, vol. 89, No. 8, Aug. 1978, p. 334, 65167s, (Kreuter).

Affiliated with

Also associated with

Rating

Process for preparing biodegradable submicroscopic particles con does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing biodegradable submicroscopic particles con, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing biodegradable submicroscopic particles con will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1988157