Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1997-09-23
1999-11-16
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564457, 564458, C07C21134
Patent
active
059861428
ABSTRACT:
The present invention provides a process for preparing compounds of Formula I: ##STR1## wherein R.sub.1 is methyl by reduction of a camphene intermediate with a reducing agent.
REFERENCES:
patent: 2831027 (1958-04-01), Pfister et al.
patent: 2972631 (1961-02-01), Bain
patent: 3304167 (1967-02-01), Buntin
patent: 3514486 (1970-05-01), Hartzler
patent: 3717650 (1973-02-01), Herr et al.
patent: 3884976 (1975-05-01), Bernauer et al.
patent: 4053511 (1977-10-01), Hoffmann
patent: 4087551 (1978-05-01), May
patent: 4837218 (1989-06-01), Olney
patent: 4898888 (1990-02-01), Baldone
patent: 5284976 (1994-02-01), Brown
Luskin, L.S. et al., "tert-Carbinamines. V. The Addition of Isothiocyanic Acid to Camphene," J. Org. Chem. 21:1430-1431 (1956).
Stein, G.A. et al., "The reaction of camphene with hydrogen cyanide," J. Am. Chem. Soc. 78:1514-1515 (1956).
Stone, C.A. et al., "Chemistry and Structure Activity Relationships of Mecamylamine and Derivatives," J. Med. Pharm. Chem. 5(4):665-690 (1962).
Suchocki, J.A. et al., "Synthesis of 2-exo-and 2-endo-Mecamylamine Analogues. Structure-Activity Relationships for Nicotinic Antagonism in the Central Nervous System," J. Med. Chem. 34:1003-1010 (1991).
CA:116:152086 abs of SU1671559 Aug. 1991.
CA:127:262429 abs of Synlett by Crousse (8) pp. 992-994 Apr. 1997.
CA:83:28678 ab of J Polym Sci, Polym Chem ED by Cohen 13 (3) pp. 745-8 1975.
CA:81:77581 abs of J Chem Soc Chem Comm by Butterick (8) pp. 307-8 1974.
Magni Ambrogio
Signorelli Giovanni
Geist Gary
Poli Industria Chimica SpA
Vollano Jean F
LandOfFree
Process for preparing bicycloheptanamine compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing bicycloheptanamine compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing bicycloheptanamine compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1326788