Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1983-07-20
1985-09-17
Trousof, Natalie
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
260465D, 260465H, 560 9, 560 17, 560 51, 560 52, 560 54, 560 59, 560 81, 560 82, 562431, 562435, 562460, 562463, 562469, 562488, 568 58, 568 63, 568 66, 568 68, 568306, 568312, 568315, 568316, 568424, 568433, 568585, 568586, 568631, 568635, 568636, 568637, C07C 67343, C07C 4569, C07C 51353, C07C12000, C07C 3714, C07C 7602, C07C 4118, C07C14800, C07C 1726, C07C 268, C07C 269
Patent
active
045422338
ABSTRACT:
Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.
REFERENCES:
patent: 3932499 (1976-01-01), Adams et al.
patent: 3992459 (1976-11-01), Utne
patent: 4052514 (1977-10-01), Adams et al.
patent: 4266069 (1981-05-01), Walker
patent: 4324904 (1982-04-01), Hylton et al.
Belli Aldo
Citterio Attilio
Piccolo Oreste
Villa Giovanni
Zen Enrico
Biaschim S.p.A.
Clarke Vera C.
Trousof Natalie
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