Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles
Patent
1997-11-07
1999-07-13
Ambrose, Michael G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitriles
546286, 546311, 549491, 560102, 568316, C07C25330, C07C 6976, C07C 4567, C07D21385, C07D21373
Patent
active
059228989
ABSTRACT:
The present invention provides a process for preparing biaryl compounds comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with an arylhalide in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a cocatalyst selected from zinc cocatalysts and cadmium cocatalysts. The present invention specifically provides a process for the preparation of 2-(4'-methylphenyl)benzonitrile comprising reacting a 4-methylphenylmagnesium reagent with a 2-halobenzonitrile in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a zinc cocatalyst.
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Farrell Robert Patrick
Miller Joseph Arthur
Ambrose Michael G.
Catalytica Pharmaceuticals, Inc.
Grate John H.
Jecminek Al A.
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