Process for preparing .beta.-hydroxy-.alpha. amino acids

Details Process for preparing .beta.-hydroxy-.alpha. amino acids Process for preparing .beta.-hydroxy-.alpha. amino acids

1992-07-22

1993-11-30

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

564503, C12P 1304, C07C21500

Patent

active

052664686

ABSTRACT:
.beta.-Hydroxy-.alpha.-amino acids are obtained via serine hydroxymethyltransferase catalyzed condensation of aldehydes with glycine. The predominant product with most aldehydes is the L-erythro diastereomer. For example, succinic semialdehyde methylester is condensed with glycine in the process to provide L-erythro .alpha.-amino hydroxy adipic acid mono methyl ester.

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patent: 5102792 (1992-04-01), Walter et al.
Webb, EC Enzyme Nomenclature 1984 pp. 154-155.
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Jung, M. and Miller, M. J., Tetrahedron Letters, vol. 26, No. 8, 977-980, 1985.
Schirch, LaVerne, J. of Biol. Chem., vol. 237, No. 8, Aug. 1962, 2578-81.
Schirch, LaVerne, Methods of Enzymology, vol. 17, Pt B, pp. 335-340.

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