Process for preparing benzoypyranol derivatives

Details Process for preparing benzoypyranol derivatives Process for preparing benzoypyranol derivatives

1990-01-30

1992-06-30

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 15, 546196, 548407, C07D40504

Patent

active

051264609

ABSTRACT:
A process for the preparation of a pure (3S,4R)-isomer of a compound of formula (A): ##STR1## wherein the substituents are herein defined in which the pyrrolidonyl or piperidonyl ring is formed by cyclizing an appropriate precursor dihydrobenzopyranol compound that has already been resolved to the (3S,4R)-configuration, or a mixture in which the (3S,4R)-configuration predominates with respect to the (3S,4R)-configuration.

REFERENCES:
Paul Newman, Optical Resolution Procedures For Chemical Compoundsvol. 1, pp. 11, 246, 256, 47. (1989).
Chemical Abstracts, vol. 019, No. 25, 1988, p. 389, Column 2, abstract-no. 230 805q and Jpn. Kokai Tokkyo Koho Jp 62,273,972 (87,273,972).
Chemical abstracts, vol. 99, No. 19, 1983, p. 595, column 2, abstract-no. 158 185t & J. Med. chem. 1983, 26(11), 1582-9.
Chemical Abstractrs, vol. 101, No. 11, 1984, p. 622, column 2, abstract-no. 90 726x & J. Med. Chem. 1984, 27((), 1127-1131.

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