Process for preparing benzimidazole-type compounds

Details Process for preparing benzimidazole-type compounds Process for preparing benzimidazole-type compounds

2005-07-19

2005-07-19

Morris, Patricia L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06919459

ABSTRACT:
The present invention relates to an improved process for the preparation of proton pump inhibitors of the benzimidazole-type such as rabeprazole, omeprazole, pantoprazole, lansoprazole and esome prazole, of general formula (1) by oxidation of the corresponding sulfide followed by extraction of the sulfone by-product with an aqueous alkaline solution at controlled pH.

REFERENCES:
patent: WO 91/18895 (1991-12-01), None
patent: WO 00/02876 (2000-01-01), None
Abstract XP002183669 Changzhou No 4 Pharm Plant 1997.

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