Process for preparing benzhydrylthioacetamide

Details Process for preparing benzhydrylthioacetamide Process for preparing benzhydrylthioacetamide

2007-07-17

2007-07-17

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

10537965

ABSTRACT:
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetamide is prepared in high yield and purity by the reaction of a haloacetamide with the reaction product of thiourea and benzhydrol in aqueous solution. The reaction employing the haloacetamide is conducted in a solvent comprising water and an organic solvent such as dimethylformamide having dissolved therein a basic salt such as potassium carbonate. The resulting benzhydrylthioacetamide can be oxidized to provide the pharmaceutical modafinil.

REFERENCES:
patent: 4066686 (1978-01-01), Lafon
patent: 4098824 (1978-07-01), Lafon
patent: 4127722 (1978-11-01), Lafon
patent: 4177290 (1979-12-01), Lafon
patent: 4489095 (1984-12-01), Lafon
patent: 4713246 (1987-12-01), Begum et al.
patent: 4880623 (1989-11-01), Piergiorgio et al.
patent: 4895726 (1990-01-01), Curtet et al.
patent: 4927855 (1990-05-01), Lafon
patent: 4952574 (1990-08-01), Banitt
patent: 5021242 (1991-06-01), Römer et al.
patent: 5180745 (1993-01-01), Lafon
patent: 5202129 (1993-04-01), Samejima et al.
patent: 5391576 (1995-02-01), Lafon
patent: 5719168 (1998-02-01), Laurent
patent: 5932707 (1999-08-01), Archer et al.
patent: 6492396 (2002-12-01), Bacon et al.
patent: 6649796 (2003-11-01), Naddaka et al.
patent: 6670358 (2003-12-01), Bacon et al.
patent: 6849120 (2005-02-01), Singer et al.
patent: 6875893 (2005-04-01), Largeau et al.
patent: 6919367 (2005-07-01), Bacon et al.
patent: 2002/0043207 (2002-04-01), Singer et al.
patent: 2002/0183552 (2002-12-01), Naddaka et al.
patent: 2004/0002547 (2004-01-01), Largeau et al.
patent: 2004/0102523 (2004-05-01), Broquaire et al.
patent: 2004/0106829 (2004-06-01), Fornaroli et al.
patent: 2005/0034652 (2005-02-01), Ceausu et al.
patent: 1432565 (2003-07-01), None
patent: 0097071 (1983-12-01), None
patent: 233106 (1987-01-01), None
patent: 0233106 (1987-08-01), None
patent: 0283362 (1988-09-01), None
patent: 1260501 (2002-11-01), None
patent: WO 94/21371 (1994-09-01), None
patent: WO 02/10125 (2002-02-01), None
patent: WO 02/30414 (2002-04-01), None
patent: WO 03/099774 (2003-12-01), None
patent: WO 2004/075841 (2004-09-01), None

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