Process for preparing benzazepine intermediates for the synthesi

Details Process for preparing benzazepine intermediates for the synthesi Process for preparing benzazepine intermediates for the synthesi

1993-09-27

1995-10-24

Datlow, Philip I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

560 27, 560 28, 560 29, 564355, 564308, 548228, C07C21770, C07C27116, C07D22314

Patent

active

054611474

ABSTRACT:
Disclosed are a process and intermediates of the formula ##STR1## wherein R is --CH.sub.3 or --C(O)--OR.sup.1, and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5 ; or the formula ##STR2## wherein: R.sup.2 is H or OH, R is --C(O)OR.sup.1 and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5, or where R.sup.2 is H, R can also be CH.sub.3 ; for preparing benzazepine intermediates of the formula ##STR3## The benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.

REFERENCES:
patent: 2160138 (1939-05-01), Gaylor
patent: 4973586 (1990-11-01), Berger et al.
Berger, et al, J. Med. Chem., 32, 1913-1921 (1989).

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