Process for preparing AZT

Details Process for preparing AZT Process for preparing AZT

1993-11-15

1995-11-14

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 284, 536 2854, C07H 100, C07H 19173

Patent

active

054667879

ABSTRACT:
A process for preparing AZT and comprising the steps of:

REFERENCES:
patent: 3202656 (1965-08-01), Abraham et al.
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4780453 (1988-10-01), Rideout et al.
patent: 4810796 (1989-03-01), Luksza
patent: 4818538 (1989-04-01), Rideout et al.
patent: 4818750 (1989-04-01), Rideout et al.
patent: 4828838 (1989-05-01), Rideout et al.
patent: 4847244 (1989-07-01), Rideout et al.
patent: 4874609 (1989-10-01), Rideout et al.
patent: 4874751 (1989-10-01), Beacham, III et al.
patent: 4916218 (1990-04-01), Almond et al.
patent: 4921950 (1990-05-01), Wilson
patent: 5041543 (1991-08-01), Shaver et al.
patent: 5093114 (1992-03-01), Rideout et al.
patent: 5145840 (1992-09-01), Kirk, III et al.
patent: 5175306 (1992-12-01), Geiger et al.
Hrebabecky et al. Carbohydrate Res. 216:179-186, 1991.
Horwitz, et al., "Nucleosides. V. The Monomesylates of 1-(2'-Deoxy-.beta.-D-lyxofuranosyl)thymine," J. Org. Chem., 29, 1964, 2076-2079.
Maillard, et al., "Synthesis of 3'-Substituted-2',3'-dideoxynucleoside Analogs as Potential Anti-AIDS Drugs," Tetrahedron Letters, 30, 1989, 1955-1958.
Chu, et al., "An Efficient Total Synthesis of 3'-Azido-3'-deoxythimidine (AZT) and 3'-Azido-Azido-2',3'-dideoxyuridine (AZDDU, CS-87) From D-Mannitol," Tetrahedron Letters, 29, 1988, 5349-5352.
Fleet, et al., "Methyl 5-O-tert-butyldiphenylsilyl-2-deoxy-.alpha..beta.-D-threo-pentofuranoside as a Divergent Intermediate for the Synthesis of 3'-Substituted-2',3'-dideosynucleosides: Synthesis of 3'-Azido-3'-deoxythimidine, 3'-Deoxy-3'-fluoro-thymidine and 3'-Cyano-3'-Cyano-3'-deoxythimidine," Tetrahedron, 44, 1988, 625-636.
Wengel, et al., "Selective Deformylation of an .alpha.,.beta.-Unsaturated Sugar aldehyde in a Very Short Synthesis of 3'-Azido-3'-3'-deoxythymidine (AZT) and is Stereoisomers," Synthesis, Jun. 1991, 451.
Hager, et al., "Cyclization Protocols for Controlling the Glycosidic Stereochemistry of Nucleosides. Application to the Synthesis of the antiviral Agent 3'-Azido-3'-Azido-3'-Deoxythymidine (AZT)," J. Am. Chem. Soc., 113, 1991, 5117-5119.
Jung, et al, "Synthetic Approaches to 3'-Azido-3'-3'-deoxythymidine and Other Modified Nucleosides," J. Org. Chem., 56, 1991, 2614-2615.
Sugimura, et al., "Coupling Reaction of 1-thiopentofuranosides With Silylated Pyrimidine Bases by Activation with N-Bromosuccinimide:Synthesis of 3',-Azido-3'-deoxythymidine and Its Related Nucleoside Analogs," Tetrahedron Letters, 32, 1991, 1813-1816.
Czernecki, et al., "An Efficient Synthesis of 3'-Azido-3'-deoxythymidine (AZT)," Synthesis, Mar. 1991, 239-240.
Chemical Abstracts, Abstract No. 158908 vol. 105, No. 17, p. 380, column R Oct. 27, 1986 (JP-A 61 70 999).

Affiliated with

Also associated with

Rating

Process for preparing AZT does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing AZT, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing AZT will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1221904