Process for preparing azetidinones

Details Process for preparing azetidinones Process for preparing azetidinones

1977-12-27

1980-02-05

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602454, 260326S, 260326N, 26032637, 2603303, 542420, C07D20508, C07D40304

Patent

active

041872215

ABSTRACT:
A process for preparing azetidinones of the formulae 1 and 2A and the stereoisomers of the latter of formula 2B ##STR1## wherein R is an amino-protecting group commonly used in penicillin chemistry and is selected from the group consisting of H, C.sub.1 -C.sub.6 alkyl, phenyl, (optionally substituted in the o-, m-, or p- positions by CH.sub.3, F, Cl, OCH.sub.3, or a nitro group), benzyl, 2-thienylmethyl, tetrazol (1-, 2-, or 5-)-ylmethyl, 2-phenyl-5-methylisoxazol-4-yl, phenoxymethyl, and R.sup.5 O-- and R.sup.5 S, wherein R.sup.5 stands for C.sub.1 -C.sub.6 alkyl, phenyl, benzyl or trichloroethyl; it should be noted that the value of R is immaterial to the process described;

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