Process for preparing azacycloalkanoylaminothiazoles (LD 137e)

Details Process for preparing azacycloalkanoylaminothiazoles (LD 137e) Process for preparing azacycloalkanoylaminothiazoles (LD 137e)

2005-05-24

2005-05-24

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06897321

ABSTRACT:
The present invention relates to new, efficient processes for the preparation of 5-(-2-oxyazolylalkylthio)-2-azacycloalkanoylaminothiazole compounds of formula Ior a pharmaceutically acceptable salt thereof, wherein:R is alkyl, aryl or heteroaryl;R1, R2, R3, R4and R5are each independently hydrogen, alkyl, aryl or heteroaryl;R6and R7are each independently hydrogen, alkyl, aryl, heteroaryl, halogen, hydroxy or alkoxy;R8is hydrogen, alkyl, aryl, heteroaryl, CONR9, R10, COR11or COOR12;R9, R10, R11and R12are each independently hydrogen, alkyl or aryl;m equals 0 to 5; andn equals 0 to 5,which are novel, potent inhibitors of cyclin dependent kinases (cdks). The present invention further concerns new key intermediate compounds, a quaternary ammonium salt of formula III′ and a 2-oxazolylalkyl derivative of formula IX.

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