Process for preparing as partyl-phenylalanine dipeptides

Details Process for preparing as partyl-phenylalanine dipeptides Process for preparing as partyl-phenylalanine dipeptides

1987-10-01

1989-10-10

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 41, C07C10108, C07C10118, C07C 9900, C07C10330

Patent

active

048733598

ABSTRACT:
Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.

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