Process for preparing aryl-substituted aliphatic carboxylic acid

Details Process for preparing aryl-substituted aliphatic carboxylic acid Process for preparing aryl-substituted aliphatic carboxylic acid

1993-05-11

1994-05-24

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 9, 560 20, 560 21, 560 55, 560 56, 560100, 562406, C07C 6976, C07C 5110

Patent

active

053150295

ABSTRACT:
A new process for preparing alkyl esters of ibuprofen is provided. A 1-halo-1-(4-isobutylphenyl)ethane is reacted with carbon monoxide in the presence of an anhydrous alcohol at a temperature between about 10.degree. C. and about 200.degree. C. An excess of several moles of alcohol is preferred. An acid such as trifluoroacetic acid is also added. As catalyst, a palladium compound and at least one acid-stable ligand over palladium are present; however, an excess of ligand over palladium is advantageous.

REFERENCES:
patent: 4990658 (1991-02-01), Stahly et al.
patent: 5254720 (1993-10-01), Wu
patent: 5260477 (1993-11-01), Shimzu

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