Process for preparing aryl piperazinyl-heterocyclic compounds wi

Details Process for preparing aryl piperazinyl-heterocyclic compounds wi Process for preparing aryl piperazinyl-heterocyclic compounds wi

1993-04-20

1994-08-16

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D41706, C07D41306

Patent

active

053388461

ABSTRACT:
A process for preparing a compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, which comprises reacting a piperazine salt of the formula ##STR2## with an alkyl halide containing compound of the formula ##STR3## in water with a reagent to neutralize the hydrohalic acid and heating the mixture under conditions which are suitable to effect the coupling of said piperazine salt with said alkyl halide containing compound.

REFERENCES:
patent: 4558060 (1985-12-01), Caignard et al.
patent: 4610988 (1986-09-01), Davis et al.
patent: 4831031 (1989-05-01), Lowe, III et al.
patent: 4883795 (1989-11-01), Lowe, III et al.
patent: 5206366 (1993-04-01), Bowles
Yevich, J. P. et al., "Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)-and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents," J. Med. Chem., 29, No. 3, pp. 359-369 (1986).

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