Process for preparing aryl piperazinyl-heterocyclic compounds

Details Process for preparing aryl piperazinyl-heterocyclic compounds Process for preparing aryl piperazinyl-heterocyclic compounds

1992-08-26

1993-04-27

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544230, 544284, 544363, 544366, 544373, 544376, C07D41706, C07D41306

Patent

active

052063666

ABSTRACT:
A process for preparing a compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, which comprises reacting a monosubstituted piperazine of the formula ##STR2## with an alkyl halide containing compound of the formula ##STR3## in water with a reagent to neutralize the hydrohalic acid and refluxing the mixture under conditions which are suitable to effect the coupling of said monosubstituted piperazines with said alkyl halide containing compound.

REFERENCES:
patent: 4558060 (1985-12-01), Caignard et al.
patent: 4610988 (1986-09-01), Davis et al.
patent: 4831031 (1989-05-01), Lowe, III et al.
patent: 4883795 (1989-11-01), Lowe, III et al.

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