Process for preparing artificial red cells

Details Process for preparing artificial red cells Process for preparing artificial red cells

1980-04-11

1983-03-08

Lovering, Richard D.

Compositions

Preservative agents

Anti-corrosion

424 36, 424177, B01J 1302, A01N 2528, A61K 950, A61K 964

Patent

active

043760597

ABSTRACT:
A process for preparing artificial red cells comprising microdroplets of aqueous, stroma-free hemoglobin solution encapsulated in membranes of polymerized hemoglobin, said process comprising forming microdroplets of hemoglobin solution in a continuous oil phase, cross-linking the hemoglobin at the surface of the microdroplets with a suitable cross-linking agent to form the artificial red cells and recovering the cells. In one embodiment, a liquid membrane encapsulation technique employing a water-soluble cross-linking agent is used to form the cells. In another embodiment an oil-soluble cross-linking agent is present in the oil phase containing the hemoglobin microdroplets.

REFERENCES:
patent: 3879510 (1975-04-01), Kitajima et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4133874 (1979-01-01), Miller et al.
Chang: "Artificial Cells", Chemtech, Feb. 1975, pp. 80-85.
Chang et al.: "Semipermeable Aqueous Microcapsules", Canadian Journal of Physiology and Pharmacology, vol. 44 (1966), pp. 115-128.

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