Process for preparing aromatic olefins by using...

Details Process for preparing aromatic olefins by using... Process for preparing aromatic olefins by using...

1999-08-20

2001-02-27

Knode, Marian C. (Department: 1764)

Chemistry of hydrocarbon compounds

Aromatic compound synthesis

Having alkenyl moiety, e.g., styrene, etc.

C585S435000, C585S438000

Reexamination Certificate

active

06194627

ABSTRACT:

The present invention relates to a new process for preparing aromatic olefins using palladaphosphacyclobutanes as novel catalysts.
Aromatic olefins, in particular cinnamic acid derivatives, styrenes and stilbenes are industrially important as fine chemicals, starting materials for polymers, UV absorbers and precursors for syntheses.
A frequently employed method of synthesizing aromatic olefins on a laboratory scale is the Heck reaction in which iodoaromatics or bromoaromatics and in exceptional cases chloroaromatics are reacted with olefins in the presence of palladium catalysts. Reviews which describe this method may be found in R. F. Heck, Acc. Chem. Res. 1979, 12, 146; R. F. Heck, Org. React. 1982, 27, 345; R. F. Heck, Palladium Reagents in Synthesis, Academic Press, London 1985.
The catalysts which are used for the Heck reaction are palladium compounds. Although both palladium(II) and palladium(0) complexes can be used in Heck reactions, it is generally accepted that only palladium(0) compounds are the actual catalysts in the reaction. In particular, coordinatively unsaturated 14-electron palladium(0) species which are generally stabilized with weak donor ligands such as phosphines are formulated in the literature.
Despite the many publications on the subject of the Heck reaction, only a few examples of an industrial application of this method are known to the present time. This is attributable to the fact that the catalyst systems described frequently give satisfactory catalytic turnover numbers only with uneconomical starting materials such as iodoaromatics. Otherwise, in the case of bromoaromatics and particularly in the case of chloroaromatics, it is generally necessary to add large amounts of catalyst, usually 1-5 mol %, in order to achieve industrially useful conversions. In addition, owing to the complexity of the reaction mixtures, no simple catalyst recycling is possible, so that the catalyst costs also generally stand in the way of industrial implementation.
DE-4421730 discloses the hitherto best process using palladaphosphaindanes, known as palladacycles, for the Heck reaction. It comprises the reaction of bromoaromatics and chloroaromatics with olefins. Activated bromoaromatics, for example 4-bromoacetophenone, 4-bromobenzaldehyde or 4-iodobromobenzene, are reacted in yields of up to 100% using amounts of from 0.002 to 0.01 mol % of palladium catalyst in the form of palladaphosphaindane. Less active bromoaromatics, for example bromotoluene or bromobenzene, are reacted in yields of up to 96% using amounts of 2 mol % of palladium as catalyst in the form of palladaphosphaindane. In the reaction of activated chloroaromatics, for example chloroacetophenone, it is necessary to add halide ions in the form of their salts, for example lithium bromide, in order to achieve high yields. Thus, the reaction of 100 mmol of 4-chloroacetophenone, 170 mmol of 2-ethylhexyl acrylate, 110 mmol of sodium acetate, 10 mmol of lithium, bromide in 100 ml of dimethylacetamide with 0.05 mmol of di-&mgr;-acetato-bis(o-(di-o-tolylphosphino)benzyl)dipalladium(II) (corresponds to 0.1 mol % of palladium) as catalyst gives a yield of 82% of 2-ethylhexyl trans-4-acetylcinnamate after 18 hours at 130° C. Since, owing to the complexity of the reaction mixtures, simple catalyst recycling is not possible when using palladaphosphaindanes either, the catalyst costs generally stand in the way of industrial implementation in the case of the less active bromoaromatics and chloroaromatics. In addition, in the case of the chloroaromatics, the addition of halides or pseudo halides is ecologically disadvantageous, especially since these do not contribute to the reaction but only serve to stabilize the palladaphosphaindanes.
There is therefore a need for a process which does not have the abovementioned disadvantages, is suitable for carrying out in industry and gives aromatic olefins in high yield and purity.
The invention provides a process for preparing aromatic olefins of the formula (I)
where
R
1a
to R
5a
are, independently of one another, hydrogen, C
1
-C
8
-alkyl, C
1
-C
8
-alkoxy, C
1
-C
8
-acyloxy, O-phenyl, phenyl, fluorine, chlorine, bromine, OH, NO
2
, OSO
2
CF
3
, CN, COOH, CHO, SO
3
H, SO
2
R, SOR, NH
2
, NH—C
1
-C
8
-alkyl, N(C
1
-C
8
-alkyl)
2
, CHal
3
, NHCO—C
1
-C
4
-alkyl, N—C
1
-C
4
-alkyl-CO—C
1
-C
4
-alkyl, COO—C
1
-C
8
-alkyl, CONH
2
, CO—C
1
-C
8
-alkyl, NHCOH, NCOO—C
1
-C
4
-alkyl, CO-phenyl, COO-phenyl, CHCH—CO
2
—C
1
-C
8
-alkyl, CHCHCO
2
H, PO(phenyl)
2
, PO(C
1
-C
4
-alkyl)
2
, OSO
2
-phenyl, OSO
2
CH
3
, where one of the radicals R
1a
to R
5a
can also be
R
6a
is hydrogen, C
1
-C
8
-alkyl, phenyl, O—C
1
-C
8
-alkyl, fluorine;
R
7a
and R
8a
are, independently of one another, hydrogen, CN, CO
2
H, CO
2
—C
1
-C
8
-alkyl, CONH
2
, CONH—C
1
-C
4
-alkyl, CON(C
1
-C
4
-alkyl)
2
, fluorine, CO
2
-phenyl, C
1
-C
8
-phenyl, PO(phenyl)
2
, PO(C
1
-C
4
-alkyl)
2
, CO-phenyl, CO—C
1
-C
4
-alkyl, O—C
1
-C
4
-alkyl, NH—C
1
-C
4
-alkyl, PO
3
H, SO
3
H, SO
3
—C
1
-C
4
-alkyl, SO
2
—C
1
-C
4
-alkyl, O-phenyl, C
1
-C
8
-alkyl,
R
3
, R
4
, R
5
, R
6
are, independently of one another, C
1
-C
8
-alkyl, C
3
-C
12
-cycloalkyl, aryl;
or where R
1
and R
2
, R
1
or R
2
and R
3
or R
4
, R
3
and R
4
, R
3
or R
4
and R
5
or R
6
, R
5
and R
6
together form an aliphatic ring having from 4 to 10 carbon atoms,
or where R
5
and R
6
, R
3
or R
4
and R
5
or R
6
together form an aromatic ring having from 5 to 9 carbon atoms, and
Y is an anion of an inorganic or organic acid,
is used as catalyst.
The process is preferably carried out using compounds of the formula (IV) in which
R
1
, R
2
are, independently of one another, phenyl,
R
5
, R
6
are, independently of one another, phenyl, naphthyl, anthracenyl which may each be substituted by from 1 to 3 C
1
-C
4
-alkyl or from 1 to 3 C
1
-C
4
-alkoxy groups, and
Y is acetate, propionate, benzoate, chloride, bromide, iodide, fluoride, sulfate, hydrogensulfate, nitrate, phosphate, tosylate, mesylate, trifluoromethanesulfonate, tetrafluoroborate, acetylacetonate, hexafluoroacetylacetonate or pyrazolyl.
The process is particularly preferably carried out using compounds of the formula (IV) in which
R
5
, R
6
are, independently of one another, o-trifluoromethylphenyl, o-trifluoromethyl-p-tolyl, o-trifluoromethyl-p-methoxyphenyl, o-methoxyphenyl, o,p-dimethoxyphenyl, o,o,p-trimethoxyphenyl, anthracenyl, tert-butyl, n-butyl, isopropyl, isobutyl, cyclohexyl, 1-methylcyclohexyl.
In particular, the compounds
di-&mgr;-acetato-bis[2-[bis(1,1-dimethylethyl)phosphino]-2-methylpropyl-C,P]dipalladium(II)
di-&mgr;-acetato-bis[2-[(1,1-dimethylethyl)phenylphosphino]-2-methylpropyl-C,P]dipalladium(II)
di-&mgr;-chloro-bis[2-[bis(1,1-dimethylethyl)phosphino]-2-methylpropyl-C,P]dipalladium(II)
di-&mgr;-chloro-bis[2-[(1,1-dimethylethyl)phenylphosphino]-2-methylpropyl-C,P]dipalladium(II)
di-&mgr;-bromo-bis[2-[bis(1,1-dimethylethyl)phosphino]-2-methylpropyl-C,P]dipalladium(II)
di-&mgr;-bromo-bis[2-[(1,1-dimethylethyl)phenylphosphino]-2-methylpropyl-C,P]dipalladium(II)
are used for the process.
As solvents, use is generally made of inert organic solvents. Well suited solvents are dipolar aprotic solvents such as dialkyl sulfoxides, N,N-dialkylamides of aliphatic carboxylic acids or alkylated lactams. Preference is given to dimethyl sulfoxide, dimethylacetamide, dimethylformamide and N-methylpyrrolidone.
The reaction proceeds at temperatures of from 20 to 200° C.; in many cases it has been found to be useful to carry it out at temperatures of from 60 to 180° C., preferably from 80 to 150° C.
Since HX is eliminated in the reaction, it is advantageous to neutralize this acid by addition of a base. Suitable bases are primary, secondary or tertiary amines such as alkylamines, dialkylamines, trialkylamines, each of which may be alicyclic or open-chain, alkali metal or alkaline earth metal salts of aliphatic or aromatic carboxylic acids or of carbonic acid, for ex

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