Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-06-23
1997-01-07
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352552, 4353201, 536 235, 536 231, 530300, C12N 1581, C12N 1515, C07K 1481, C12P 2102
Patent
active
055916031
ABSTRACT:
The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity and/or reduced nephrotoxicity compared to native aprotinin, as well as compositions comprising such analogs.
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Bj.o slashed.rn Soren E.
Bregengaard Claus
Christensen Niels D.
Diness Viggo
N.o slashed.rskov-Lauritsen Leif
Agris, Esq. Cheryl H.
Draper Garnette D.
Novo Nordisk A S
Teng Sally P.
Zelson Esq. Steve T.
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