Process for preparing antiviral antibiotic BU-3889V

Details Process for preparing antiviral antibiotic BU-3889V Process for preparing antiviral antibiotic BU-3889V

1991-03-11

1992-06-23

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424 858, 424114, 424115, 424117, 4241951, 435 74, 435169, 4352521, 435822, 514 25, C12R 101, A61K 3500, C12N 120

Patent

active

051241501

ABSTRACT:
Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.

REFERENCES:
patent: 4920215 (1990-04-01), Holdom et al.

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