Process for preparing antibiotic L 17046

Details Process for preparing antibiotic L 17046 Process for preparing antibiotic L 17046

1985-09-20

1987-10-06

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530332, C07K 512

Patent

active

046984186

ABSTRACT:
This invention relates to a process for converting a teicoplanin-like compound into antibiotic L 17046 characterized in that a teicoplanin-like compound selected from teicoplanin complex, any further purified preparation thereof, teicoplanin factor A.sub.2, teicoplanin factor A.sub.3, each of the main components of teicoplanin factor A.sub.2, antibiotic L 17054 and a mixture of two or more of the above substances in any proportion is submitted to hydrolysis with a strong acid in the presence of a polar aprotic organic solvent selected from ethers, ketones and mixtures thereof that a room temperature are liquid.

REFERENCES:
patent: 4594187 (1986-06-01), Strazzolini et al.
patent: 4629781 (1986-12-01), Strazzolini et al.
patent: 4645827 (1987-02-01), Malabarba et al.
A. Malabarba, et al., J. Antibiotics 37(9), 988 (1984).
J. C. J. Barna, et al., J. Amer. Chem. Soc. 106(17), 4896, (1984).

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