Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1995-04-26
1997-03-25
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435212, C12P 2102
Patent
active
056143796
ABSTRACT:
The present invention is directed to a novel process of preparing an anti-obesity protein using dipeptidyl-aminopeptidase isolated from the cellular slime mold, Dictyostelium discodeum. The process produces an anti-obesity protein in high yield.
REFERENCES:
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Flam, "Obesity Gene Discovery May Help Solve Weighty Problem", Science, 266, 1477-1478 (Dec. 2, 1994).
Chan, et al., "Dipeptidyl-Aminopeptidases and Aminopeptidases in Dictyostelium discoideum", Biochemical and Biophysical Research Communications, 127:3, 962-968 (Mar. 29, 1985).
Chan, et al., "Partial Purification and Characterization of Dipeptidyl-aminopeptidase III from Dictyostelium discoideum", Experimental Mycology, 11, 27-35 (1987).
Hutchinson, et al., "The preparation and properties of immobilised dipeptidyl-aminopeptidase I (cathepsin C)", Biochimica et Biophysica Acta, 916, 1-4 (1987).
Erickson, et al., "Interaction of Purified Brush Border Membrane Aminopeptidase N and Dipeptidyl Peptidase IV with Lectin-Sepharose Derivatives", Biochimica et Biophysica Acta, 743, 37-42 (1983).
Huang, et al. "The Purification, Specificity, and Role of Dipeptidyl Peptidase III in Dictyostelium discoideum", Experimental Mycology, 16, 102-109 (1992).
Boone David E.
Caltrider Steven P.
Eli Lilly and Company
Lilling Herbert J.
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