Process for preparing anti-inflammatory cycloalkylidenemethylphe

Details Process for preparing anti-inflammatory cycloalkylidenemethylphe Process for preparing anti-inflammatory cycloalkylidenemethylphe

1985-06-28

1987-06-16

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560051, 2605011, 26050111, C07C 5986

Patent

active

046737618

ABSTRACT:
Cycloalkylidenemethylphenylacetic acid derivatives of formula (I): ##STR1## (wherein R.sup.1 represents hydrogen or alkyl and n is an integer from 1 to 3) are prepared by reacting a benzaldehyde acid compound of formula (II): ##STR2## with an enamine derivative of formula (III): ##STR3## (wherein R.sup.2 and R.sup.3 are various organic groups) and then hydrolizing the product. The use of the acid of formula (II) rather than its corresponding ester enables the reaction to be effected with a good yield and under moderate and economical reaction conditions.

REFERENCES:
patent: 4254274 (1981-03-01), Terader et al.

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