Process for preparing anthranylaldehyde derivatives

Details Process for preparing anthranylaldehyde derivatives Process for preparing anthranylaldehyde derivatives

1978-12-27

1980-02-12

Niebling, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260566R, 562452, 562456, 562457, C07C 91161, C07C 9128

Patent

active

041883438

ABSTRACT:
Improved process for preparing anthranylaldehyde derivatives of formula: ##STR1## (Z.sup.1 and Z.sup.2 each represents hydrogen atom, a halogen atom, methyl group or trifluoromethyl group.) is provided.
The process comprises steps of (1) protecting aldehyde group of a o-halogenobenzaldehyde with a specific alkylamine derivative, then (2) reacting the thus protected compound with a corresponding aniline derivative, and finally, (3) treating the thus obtained product with an acid.
The anthranylaldehyde derivatives, i.a. N-(2,6-dichlorophenyl)anthranylaldehyde is useful as an intermediate for preparation of the corresponding anilinophenylacetic acids which are anti-inflammatory and analgesic agents.

REFERENCES:
patent: 3558690 (1971-01-01), Sallmann et al.

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