Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfonic acids or salts thereof
Patent
1993-10-06
1997-02-25
Kelly, Cynthia Harris
Organic compounds -- part of the class 532-570 series
Organic compounds
Sulfonic acids or salts thereof
C07C30332
Patent
active
056061080
ABSTRACT:
The preferred oligomers of the present invention are polyureas having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. These oligomers are prepared by reacting an aromatic diamine with a difunctional electrophile, in the presence of an acid acceptor, in water as the solvent or water with up to about 1 mole of water immiscible cosolvent, at a temperature of from 0.degree. to 100.degree. C. and at a pH between about 7 to about 9. The oligomers are useful for the treatment and/or diagnosis of AIDS and ARC.
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Harris Kelly Cynthia
Kimble Karen L.
Merrell Pharmaceuticals Inc.
Svoboda Craig G.
The Dow Chemical Co.
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