Process for preparing and isolating rac -bicalutamide and...

Details Process for preparing and isolating rac -bicalutamide and... Process for preparing and isolating rac -bicalutamide and...

2006-09-05

2006-09-05

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C514S520000, C514S521000, C514S523000, C514S618000, C564S162000

Reexamination Certificate

active

07102026

ABSTRACT:
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof. The present invention further discloses a new process for the isolation and purification of racemic and optically active bicalutamide.

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