Process for preparing analgesic compounds

Details Process for preparing analgesic compounds Process for preparing analgesic compounds

1997-01-28

1998-05-26

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544124, 544242, 544360, 546186, 546187, 546226, 546207, 546214, C07D40314, C07D40214

Patent

active

057567301

ABSTRACT:
A process for preparing a compound of the formula (I) ##STR1## in which, R.sup.1 and R.sup.2 are the same or different and each is hydrogen or C.sub.1 -C.sub.6 alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocyclic ring which is unsubstituted or substituted and is a 5-membered or 6-membered N-heterocycle which optionally has a further heteroatom which is oxygen, nitrogen or sulfur; E is methylene; ring A is a unsubstituted or unsubstituted aryl ring, or a substituted or an unsubstituted heteroaryl ring; R.sup.3 is a C.sub.1 -C.sub.6 alkyl and R.sup.4 is hydrogen, or R.sup.3 and R.sup.4 together are a group of the formula --(CR.sup.a R.sup.b).sub.m --C(.dbd.Y)-- (IV), wherein each of R.sup.a and R.sup.b is hydrogen or C.sub.1 -C.sub.3 alkyl, provided that there are not more than three alkyl groups in the formula (IV), m is 1, 2, or 3, and Y is two hydrogens or an oxygen; or a pharmaceutically acceptable salt thereof; which process comprises reacting an acid of the formula (II) ##STR2## with an amine of the following formula (III) ##STR3##

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